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The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosterone. They were given weekly doses of testosterone for six months. Subjects attended for assessment of changes in weight, composition, and other laboratory biomarkers. The effects of testosterone treatment and of placebo on fasting glucose, insulin, and leptin were compared according to the hypothesis that testosterone would reduce fat mass and thus improve the metabolic advantage conferred by the low fat diet in these men. The testosterone-treated men lost almost a quarter of a kg fat mass and increased their fasting glucose from a mean of 4.8 (SD 3.6) to 6.3 (SD 3.6) mmol/l, whereas the placebo men lost only 0.6 kg and showed no significant changes. There was no significant difference in these findings between men treated with testosterone and men treated with placebo. The effect of testosterone treatment on weight gain over the six months was not different from that of placebo. These results clearly indicate that testosterone does not interfere with the favourable effects of a low-fat high-carbohydrate weight loss diet observed in high-testosterone men.
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